Hydrogel Fiber Cultivation Method for Forming Bacterial Cellulose Microspheres

Micromachines

Kazuhiko Higashi¹  Norihisa Miki¹ 

[1] School of Integrated Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Kanagawa, Japan;

关键词: microbeads;    microcarriers;    microbes;    microfabrication;    microfluidics;    droplet;    emulsion;    monodispersity;   

DOI  :  10.3390/mi9010036

来源: DOAJ

【 摘 要 】

Forming microspheres or microbeads from nanofibrous materials has recently attracted research interest for their applications in various fields, because these structures greatly impact cellular behaviors and functions. However, conventional methods of preparing microspheres or microbeads have limitations, such as limited variety of material. Here, we propose a new fabrication process for forming a nanofibrous microsphere composed of bacterial cellulose (BC), which is synthesized through fermentation by specific bacteria. The process uses a hydrogel fiber containing spherical cavities. The bacteria encapsulated into the cavities produce BC, resulting in the formation of BC microspheres. Because of its simplicity, robustness, and cost-effectiveness, this process is promising for applications, such as in biochemical engineering and cell delivery systems.

【 授权许可】

Unknown