GC-04. Studies on therapeutic potential of a radiopharmaceutical based on polymer capsules with incorporated 188Re isotope for the treatment of inflammatory joint diseases

Cellular Therapy and Transplantation

article

Alisa S. Postovalova¹  Timofey E. Karpov¹  Nikolay A. Kostenikov²  Dmitry S. Sysoev²  Dmitry O. Antuganov²  Darya R. Akhmetova¹  Albert R. Muslimov¹  Alexander S. Timin¹ 

[1] Peter The Great St. Petersburg Polytechnic University;A. M. Granov Russian Research Center of Radiology and Surgical Technologies

关键词: Arthritis;    synovectomy;    microcarriers;    radionuclide therapy;    rhenium.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-3-1-132

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Arthritis is a heterogeneous group of diseases that affect one or more joints and are caused by inflammatory damage of various genesis, by involving the synovial membrane, capsule, cartilage and other components of the joint. Inflammatory diseases of the joints (IDJ) occur in 0.3-3% of the population worldwide. In particular, they affect 21% of adults in Russia. The joint swelling, stiffness of movements and chronic pain are observed in arthritis, thus altering normal working capacity, and often leading to disability. Development of novel drugs for the treatment of arthritis is an urgent task, due to variety of the IJD lesions and common inefficiency of basic, biological and glucocorticosteroid therapy. Radiopharmaceuticals show a number of advantages over radiation and chemotherapy used in the IDJ treatment. Hence, the aim of the study was to develop a radiopharmaceutical of a complex composition and evaluate its therapeutic effect in the animal model of arthritis.

【 授权许可】

CC BY