Autworks: a cross-disease network biology application for Autism and related disorders

BMC Medical Genomics

关键词: Autism;    Autistic disorder;    Autism spectrum disorders;    Autism genetics;    Autism genomics;    Network biology;    Network medicine;    Translational bioinformatics;    Protein-protein interactions;   

DOI  :  10.1186/1755-8794-5-56

来源: DOAJ

【 摘 要 】

Abstract

Background

The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results.

Description

We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis.

Conclusions

Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.

Availability: http://autworks.hms.harvard.edu/

【 授权许可】

Unknown