Autworks: a cross-disease network biology application for Autism and related disorders

BMC Medical Genomics

Dennis P Wall²  Kristian Che StGabriel¹  Byron K Hinebaugh¹  Todd F DeLuca¹  Jae-Yoon Jung¹  Tristan H Nelson² 

[1] The Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA;Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA

关键词: Protein-protein interactions;    Translational bioinformatics;    Network medicine;    Network biology;    Autism genomics;    Autism genetics;    Autism spectrum disorders;    Autistic disorder;    Autism;   

Others  :  1121280
DOI  :  10.1186/1755-8794-5-56

 received in 2012-05-29, accepted in 2012-11-22,  发布年份 2012

【 摘 要 】

Background

The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results.

Description

We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis.

Conclusions

Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.

Availability: http://autworks.hms.harvard.edu/ webcite

【 授权许可】

   
2012 Nelson et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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