The Applications of Microphysiological Systems in Biomedicine: Impact on Urologic and Orthopaedic Research

Encyclopedia

Janosch Schoon¹  Pedro Caetano-Pinto² 

[1] Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, 17475 Greifswald, Germany;Department of Urology, University Medicine Greifswald, 17475 Greifswald, Germany;

关键词: microphysiological systems;    advanced cell culture;    kidney-on-a-chip;    bone-on-a-chip;   

DOI  :  10.3390/encyclopedia2020075

来源: DOAJ

【 摘 要 】

Microphysiological systems (MPSs) are in vitro models that can incorporate dynamic stimuli such as flow, pressure and contraction in cell culture, enabling the formation of cellular architectures and retrieving physiological function often absent in conventional 2D-cell culture. MPS applications saw a substantial growth in recent years, drawing attention from industry as a strategy to optimize pre-clinical drug-development purposes, as well as from biomedical research, to fill a gap between in vivo and in vitro models. Several MPS platforms are now available and are employed in the development of bone and kidney complex systems for urologic and orthopaedic research. These advances have enabled, for example, the in vitro modelling of bone regeneration and renal drug secretion, and have dramatic potential to improve research into both orthopaedic and urology cancers.

【 授权许可】

Unknown