期刊论文详细信息
International Journal of Molecular Sciences | |
Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing | |
Jimmy Tsz Hang Lee1  Zhe Huang1  Kewu Pan1  Chi-Ming Wong1  | |
[1]State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Shenzhen Institute of Research and Innovation, The University of Hong Kong, L8-43, 21 Sassoon Road, Pokfulam, Hong Kong, China | |
关键词: pre-mRNA splicing; RNA surveillance; exosome; microRNA processing; mirtron; circular RNA; | |
DOI : 10.3390/ijms16035682 | |
来源: DOAJ |
【 摘 要 】
A processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression.【 授权许可】
Unknown