Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing

International Journal of Molecular Sciences

Kewu Pan¹  Jimmy Tsz Hang Lee¹  Zhe Huang¹  Chi-Ming Wong² 

[1] State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Shenzhen Institute of Research and Innovation, The University of Hong Kong, L8-43, 21 Sassoon Road, Pokfulam, Hong Kong, China;

关键词: pre-mRNA splicing;    RNA surveillance;    exosome;    microRNA processing;    mirtron;    circular RNA;   

DOI  :  10.3390/ijms16035682

来源: mdpi

【 摘 要 】

RNA processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.