Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration

Journal of Cardiovascular Development and Disease

Ming-Tao Zhao¹  Sanika Joshi²  Angello Huerta Gomez²  Yong Yang²  Huaxiao Yang²  Johnathan D. Tune³ 

[1] Center for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43215, USA;Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA;Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA;

关键词: Notch signaling;    cardiovascular cells;    bioengineering;    microfluidics;    hydrogel;    spheroid;   

DOI  :  10.3390/jcdd8100125

来源: DOAJ

【 摘 要 】

The Notch intercellular signaling pathways play significant roles in cardiovascular development, disease, and regeneration through modulating cardiovascular cell specification, proliferation, differentiation, and morphogenesis. The dysregulation of Notch signaling leads to malfunction and maldevelopment of the cardiovascular system. Currently, most findings on Notch signaling rely on animal models and a few clinical studies, which significantly bottleneck the understanding of Notch signaling-associated human cardiovascular development and disease. Recent advances in the bioengineering systems and human pluripotent stem cell-derived cardiovascular cells pave the way to decipher the role of Notch signaling in cardiovascular-related cells (endothelial cells, cardiomyocytes, smooth muscle cells, fibroblasts, and immune cells), and intercellular crosstalk in the physiological, pathological, and regenerative context of the complex human cardiovascular system. In this review, we first summarize the significant roles of Notch signaling in individual cardiac cell types. We then cover the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting, which are currently being used for modeling and studying Notch signaling in the cardiovascular system. At last, we provide insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.

【 授权许可】

Unknown