Occupational history of night shift work and Parkinson’s disease in Denmark

Scandinavian Journal of Work, Environment & Health

Christina Funch Lassen¹  Beate Ritz¹  Jørgen H Olsen¹  Line Kenborg¹  Johnni Hansen¹  Eva S Schernhammer² 

[1] ;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.;

关键词: denmark;    neurodegenerative disease;    parkinson’s disease;    circadian disruption;    occupational history;    night shift work;    parkinson;    shift work;    night work;    circadian;    circadian rhythm;    rotating shift work;   

DOI  :  10.5271/sjweh.3502

来源: DOAJ

【 摘 要 】

OBJECTIVES: We investigated whether working night shifts was associated with the risk of Parkinson’s disease (PD). METHODS: Between January 2008 and December 2010, we recruited 1808 patients with a confirmed diagnosis of idiopathic PD from Denmark and 1876 population controls matched by year of birth and gender. Information on lifelong occupational history, including information on night work, smoking, caffeine and alcohol consumption habits, and family history of PD was collected through structured telephone interviews. RESULTS: Overall, there was no association between a history of night shift work and PD [odds ratio (OR) for any type of night work (ie, either permanent or rotating night work) 1.01, 95% confidence interval (95% CI) 0.86–1.21]. Compared with persons who never worked night shifts, risks of those with longer durations of night work did not appear to differ (OR_<10 years=0.95, 95% CI 0.75–1.19, OR_10-19 years= 1.09, 95% CI 0.77–1.53, OR_≥20 years=1.05, 95% CI 0.81–1.37, P for trend=0.23). Associations were similar among men and women. CONCLUSIONS: These data suggest that working night shifts is not associated with PD or that low tolerance for night shift work is an early marker of PD. Due to the novel and exploratory nature of these findings, confirmation is needed.

【 授权许可】

Unknown