Occupational and recreational physical activity and Parkinson’s disease in Denmark

Scandinavian Journal of Work, Environment & Health

Christina Funch Lassen¹  Charlotte Starhof¹  Zeyan Liew¹  Johnni Hansen¹  Beate Ritz² 

[1] ;Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, California, USA, 650 Charles E. Young Drive, Los Angeles, CA 90095-1772, USA.;

关键词: work;    work;    job exposure matrix;    recreational physical activity;    work;    exercise;    physical activity;    denmark;    occupational physical activity;    leisure-time physical activity;    parkinson’s disease;   

DOI  :  10.5271/sjweh.3633

来源: DOAJ

【 摘 要 】

OBJECTIVES: This study aimed to examine whether occupational and physical activity (PA) at different ages contribute to Parkinson’s disease (PD) risk in a large population-based case-control study in Denmark. METHODS: We identified 1828 PD patients from the Danish National Hospital Register and recruited 1909 gender and year of birth matched controls from the Danish Central Population Register. Occupational and leisure-time PA were determined from a job exposure matrix based on occupational history and self-reported leisure-time information. RESULTS: No association was found for occupational PA alone in men, but higher leisure-time PA (≥5 hours/week of strenuous activities) in young adulthood (15–25 years) was associated with a lower PD risk (adjusted odds ratio (OR_adj) 0.75, 95% confidence interval (95% CI) 0.62–0.90); men who engaged in high occupational and high leisure-time PA in young adulthood had the lowest PD risk (OR_adj 0.58, 95% CI 0.41–0.81). Among women, inverse associations were found for occupation PA before age 50 (highest vs lowest, OR_adj 0.75, 95% CI 0.55–1.06) and strenuous leisure-time PA after age 50 (OR_adj 0.65, 95% CI 0.87–0.99); no clear pattern was seen for leisure and occupational PA combined. CONCLUSIONS: We observed gender-specific inverse associations between occupational and leisure-time PA and PD risk; however, we cannot preclude reverse causation especially in older ages since PD has a long prodromal stage that might lead to a reduction of PA years before motor symptom onset and PD diagnosis.

【 授权许可】

Unknown