New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Frontiers in Physiology

Tongtian Zhuang¹  Feng Wu²  Xiao Lin³  Jia-Yu Zhong⁴  Su-Kang Shan⁴  Bei Guo⁴  Feng Xu⁴  Yi Wang⁴  Fuxingzi Li⁴  Qiu-Shuang Xu⁴  Ullah Muhammad Hasnain Ehsan⁴  Ling-Qing Yuan⁴  Ming-Hui Zheng⁴ 

[1] Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China;Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China;

关键词: adipocytokines;    CTRP3;    insulin resistance;    therapeutic targets;    type 2 diabetes mellitus;    obesity;   

DOI  :  10.3389/fphys.2020.570270

来源: DOAJ

【 摘 要 】

Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

【 授权许可】

Unknown