期刊论文详细信息
Cells
The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1
Mélanie Bonhivers1  Derrick R. Robinson1  Doranda Perdomo1 
[1] CNRS, Microbiology Fundamental and Pathogenicity, UMR 5234, F-33000 Bordeaux, France;
关键词: TbBILBO1;    flagellar pocket;    flagellar pocket collar;    cytoskeleton;    flagellum;    trypanosome;    polymer;    neglected tropical diseases;   
DOI  :  10.3390/cells5010009
来源: DOAJ
【 摘 要 】

Sub-species of Trypanosoma brucei are the causal agents of human African sleeping sickness and Nagana in domesticated livestock. These pathogens have developed an organelle-like compartment called the flagellar pocket (FP). The FP carries out endo- and exocytosis and is the only structure this parasite has evolved to do so. The FP is essential for parasite viability, making it an interesting structure to evaluate as a drug target, especially since it has an indispensible cytoskeleton component called the flagellar pocket collar (FPC). The FPC is located at the neck of the FP where the flagellum exits the cell. The FPC has a complex architecture and division cycle, but little is known concerning its organization. Recent work has focused on understanding how the FP and the FPC are formed and as a result of these studies an important calcium-binding, polymer-forming protein named TbBILBO1 was identified. Cellular biology analysis of TbBILBO1 has demonstrated its uniqueness as a FPC component and until recently, it was unknown what structural role it played in forming the FPC. This review summarizes the recent data on the polymer forming properties of TbBILBO1 and how these are correlated to the FP cytoskeleton.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:2次