Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

Exploration

John Joseph¹  Jun Zhou¹  Omid C. Farokhzad¹  Zhongyang Zhang¹  Wei Tao¹  Nitin Joshi¹  Wei Chen¹  Bijan Emiliano Ferdows¹  Na Kong¹  Dylan Neal Patel¹  Donato Cosco²  Giuseppe Banfi³  Roberto Molinaro⁴  Xingcai Zhang⁵  Claudia Corbo⁶ 

[1] Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA;Department of Health Science Campus Universitario‐Germaneto “Magna Græcia” University of Catanzaro Catanzaro Italy;IRCCS Galeazzi Milano Italy;IRCCS San Raffaele Hospital Milano Italy;School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USA;School of Medicine and Surgery Nanomedicine Center Nanomib University of Milano‐Bicocca Vedano al Lambro Italy;

关键词: biomaterials;    bone defects;    nanomedicine;    scaffolds;    tissue engineering;   

DOI  :  10.1002/EXP.20210011

来源: DOAJ

【 摘 要 】

Abstract Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health resources. Various pathological conditions cause bone defects including trauma, tumors, inflammation, osteoporosis, and so forth. Auto‐ and allograft transplantation have been developed as the most commonly used clinic treatment methods, among which autologous bone grafts are the golden standard. Yet the repair of bone defects, especially large‐volume defects in the geriatric population or those complicated with systemic disease, is still a challenge for regenerative medicine from the clinical perspective. The fast development of biomaterials and nanomedicine favors the emergence and promotion of efficient bone regeneration therapies. In this review, we briefly summarize the progress of novel biomaterial and nanomedical approaches to bone regeneration and then discuss the current challenges that still hinder their clinical applications in treating bone defects.

【 授权许可】

Unknown