Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank

International Journal for Equity in Health

Nina P. Kathiresan¹  Aniruddh P. Patel²  Amit V. Khera²  Manuel A. Rivas³  Manish D. Paranjpe⁴ 

[1] Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard;Center for Genomic Medicine and Division of Cardiology, Department of Medicine, Massachusetts General Hospital;Department of Biomedical Data Science, Stanford University;Harvard Medical School;

关键词: Race;    Health disparity;    Socioeconomic deprivation;    COVID-19;   

DOI  :  10.1186/s12939-020-01227-y

来源: DOAJ

【 摘 要 】

Abstract Preliminary reports suggest that the Coronavirus Disease 2019 (COVID− 19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. We investigate the racial and socioeconomic associations of COVID− 19 hospitalization among 418,794 participants of the UK Biobank, of whom 549 (0.13%) had been hospitalized. Both Black participants (odds ratio 3.7; 95%CI 2.5–5.3) and Asian participants (odds ratio 2.2; 95%CI 1.5–3.2) were at substantially increased risk as compared to White participants. We further observed a striking gradient in COVID− 19 hospitalization rates according to the Townsend Deprivation Index − a composite measure of socioeconomic deprivation − and household income. Adjusting for socioeconomic factors and cardiorespiratory comorbidities led to only modest attenuation of the increased risk in Black participants, adjusted odds ratio 2.4 (95%CI 1.5–3.7). These observations confirm and extend earlier preliminary and lay press reports of higher morbidity in non-White individuals in the context of a large population of participants in a national biobank. The extent to which this increased risk relates to variation in pre-existing comorbidities, differences in testing or hospitalization patterns, or additional disparities in social determinants of health warrants further study.

【 授权许可】

Unknown