Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

Frontiers in Physiology

Josephine H. Naish¹  Geoff J. M. Parker²  Sarah Al-Bachari⁵  Hedley C. A. Emsley⁵  Laura M. Parkes⁶ 

[1] Bioxydyn Limited, Manchester, United Kingdom;Centre for Medical Image Computing, Department of Computer Science and Department of Neuroinflammation, University College London, London, United Kingdom;Department of Neurology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom;Division of Cardiovascular sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom;Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom;Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom;Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom;

关键词: blood–brain barrier;    cerebrovascular disease;    dynamic contrast enhanced MRI;    Parkinson’s disease;    neurovascular unit;   

DOI  :  10.3389/fphys.2020.593026

来源: DOAJ

【 摘 要 】

BackgroundBlood–brain barrier (BBB) disruption has been noted in animal models of Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.ObjectiveTo determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease.MethodsDynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB (Ktrans) and plasma volume (vp) were produced using Patlak analysis. Differences in Ktrans and vp were assessed with voxel-based analysis as well as in regions associated with PD pathophysiology. In addition, the volume of white matter lesions (WMLs) was obtained from T2-weighted fluid attenuation inversion recovery (FLAIR) images.ResultsHigher Ktrans, reflecting higher BBB leakage, was found in the PD group than in the CN group using voxel-based analysis; differences were most prominent in the posterior white matter regions. Region of interest analysis confirmed Ktrans to be significantly higher in PD than in CN, predominantly driven by differences in the substantia nigra, normal-appearing white matter, WML and the posterior cortex. WML volume was significantly higher in PD compared to CN. Ktrans values and WML volume were similar in PD and CP, suggesting a similar burden of cerebrovascular disease despite lower cardiovascular risk factors.ConclusionThese results show BBB disruption in PD.

【 授权许可】

Unknown