Primed to Sleep: The Dynamics of Synaptic Plasticity Across Brain States

Frontiers in Systems Neuroscience

Marcos G. Frank¹  Julie Seibt² 

[1] Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University Spokane, Spokane, WA, United States;Surrey Sleep Research Centre, University of Surrey, Guildford, United Kingdom;

关键词: sleep;    experience;    plasticity;    tagging;    excitability;    priming;   

DOI  :  10.3389/fnsys.2019.00002

来源: DOAJ

【 摘 要 】

It is commonly accepted that brain plasticity occurs in wakefulness and sleep. However, how these different brain states work in concert to create long-lasting changes in brain circuitry is unclear. Considering that wakefulness and sleep are profoundly different brain states on multiple levels (e.g., cellular, molecular and network activation), it is unlikely that they operate exactly the same way. Rather it is probable that they engage different, but coordinated, mechanisms. In this article we discuss how plasticity may be divided across the sleep–wake cycle, and how synaptic changes in each brain state are linked. Our working model proposes that waking experience triggers short-lived synaptic events that are necessary for transient plastic changes and mark (i.e., ‘prime’) circuits and synapses for further processing in sleep. During sleep, synaptic protein synthesis at primed synapses leads to structural changes necessary for long-term information storage.

【 授权许可】

Unknown