Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B

International Journal of Environmental Research and Public Health

Yi-lin Liu¹  Dan Liu¹  Xing-huang Chen¹  Bin Liu¹  Shi-ming Li¹ 

[1] College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;

关键词: caenorhabditis elegans;    uv-b;    quercetin;    luteolin;    lycopene;    apoptosis;    stress resistance;   

DOI  :  10.3390/ijerph17051572

来源: DOAJ

【 摘 要 】

Ultraviolet B (UV-B, 280−320 nm) radiation causes complex molecular reactions in cells, including DNA damage, oxidative stress, and apoptosis. This study designed a mixture consisting of quercetin, luteolin and lycopene and used Caenorhabditis elegans as a model to study the resistance of these natural chemicals to UV-B. Specifically, we have confirmed that quercetin and its mixture can increase the resistance of Caenorhabditis elegans to UV-B through lifespan test, reactive oxygen species level assay, germ cell apoptosis test, embryonic lethal test and RT-qPCR experiments. The results show that quercetin and its mixture prolonged the lifespan of UV-B-irradiated Caenorhabditis elegans and reduced abnormal levels of reactive oxygen species, embryo death, and apoptosis induced by UV-B. The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13. Therefore, the results of this research could help the development of UV-B radiation protection agents.

【 授权许可】

Unknown