The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Frontiers in Neuroscience

Changlian Zhu¹  Dengna Zhu²  Chao Gao³  Qing Shang³  Dan Bi⁴  Yiran Xu⁶  Xiaoli Zhang⁶  Xiaoyang Wang⁶  Juan Song⁶  Lei Xia⁶  Yangyi Fan⁷  Yimeng Qiao⁷  Yangong Wang⁷  Yu Su⁷  Qinghe Xing⁸ 

[1] Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Child Rehabilitation Center, The 3rd Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Pediatrics, Children's Hospital of Zhengzhou University and Henan Children's Hospital, Zhengzhou, China;Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China;Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden;Henan Key Laboratory of Child Brain Injury, Department of Pediatrics, The 3rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Zhengzhou, China;Institutes of Biomedical Science and Children's Hospital, Fudan University, Shanghai, China;Shanghai Center for Women and Children's Health, Shanghai, China;

关键词: cerebral palsy;    inflammatory cytokines;    interleukin;    gene polymorphism;    IL23R;   

DOI  :  10.3389/fnins.2020.590098

来源: DOAJ

【 摘 要 】

Background: Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP.Methods: We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between IL-23R single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case–control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out.Results: There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (Pallele = 0.014 and 0.048, respectively; Pgenotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (Pgenotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (Pgenotype = 0.024 after correction) and neonatal encephalopathy (Pgenotype = 0.024 after correction).Conclusion: The present results showed a significant association between IL-23R and CP, suggesting that IL-23R may play a potential role in CP pathogenesis.

【 授权许可】

Unknown