Biomarkers for Lifetime Caries-Free Status

Journal of Personalized Medicine

ArianaM. Kelly¹  Adriana Modesto¹  AlexandreR. Vieira¹  Mariana Bezamat¹ 

[1] School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA;

关键词: dental caries;    edentulism;    genomics;   

DOI  :  10.3390/jpm11010023

来源: DOAJ

【 摘 要 】

The purpose of this study was to address the hypothesis that extreme outcomes of dental caries, such as edentulism or prematurely losing permanent teeth are associated with genetic variation in enamel-formation genes. After scanning 6206 individuals, samples of 330 were selected for this study. Tested phenotypes included patients who were edentulous by age 30, patients with missing first molars by age 30, patients with missing second molars by age 30, and caries-free patients. Fourteen single nucleotide polymorphisms were genotyped by TaqMan chemistry. The analyses of each phenotype were performed using the software PLINK with an alpha of 0.05. Nominal associations were found between rs12640848 in enamelin (p = 0.05), rs1784418 in matrix metallopeptidase 20 (p = 0.02), and rs5997096 in the tuftelin interacting protein 11 and being caries-free at the age of 60. When combining patients that were missing both first mandibular molars and missing both second mandibular molars, no associations were found. Matrix metallopeptidase 20, and tuftelin interacting protein 11 also showed trends for association with being caries-free. Genetic variation in TFIP11, MMP20, and ENAM may have a protective effect increasing the chances of individuals preserving their teeth caries-free over a lifetime.

【 授权许可】

Unknown