Facile One-Pot Synthesis of Hyperbranched Glycopolymers in Aqueous Solution via a Hydroxy/Cu(III) Redox Process

Polymers

Yuangong Zhang¹  Ying Zheng²  Libin Bai²  Hailei Zhang²  Qian Zhou²  Xiaohui Hao³  Feng Liu³ 

[1] College of Basic Medicine, Hebei University, Baoding 071002, China;College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;College of Physics Science & Technology, Hebei University, Baoding 071002, China;

关键词: hyperbranched glycopolymer;    Cu(III);    redox;    amyloid fibrillation;   

DOI  :  10.3390/polym12092065

来源: DOAJ

【 摘 要 】

In this study, a self-condensing vinyl copolymerization/redox (SCVP/Redox) system was constructed to prepare hyperbranched poly(methyl-6-O-methacryloyl-α-D-glucoside) by using Cu(III) as the initiator in aqueous solution, in which the –OH group in C-2, C-3 and C-4 position on pyranose rings could be initiated by Cu(III). The branched and linear units were clearly distinguished by nuclear magnetic resonance (¹H NMR) to estimate the degree of branching (DB). When the ratio of Cu(III) to monomer fixed at 0.5:1, the DB value reached 0.32, which was higher than the product initiated by Ce(IV). Moreover, the inhibition activity of the products on amyloid fibrillation was investigated by using the hen egg-white lysozyme (HEWL) as a model based on the difference of the initiation sites. The results showed that the –OH groups in C-4 position might play an important role in this process.

【 授权许可】

Unknown