Electron paramagnetic resonance: A powerful tool of medical biochemistry in discovering mechanisms of disease and treatment prospects

Journal of Medical Biochemistry

Spasojević Ivan¹ 

[1] Institute for Multidisciplinary Research, Belgrade;

关键词: epr;    free radicals;    oxidative status;    oxidative stress;    antioxidants;   

DOI  :  

来源: DOAJ

【 摘 要 】

In pathophysiological conditions related to oxidative stress, the application of selected antioxidants could have beneficial effects on human health. Electron paramagnetic resonance (EPR) spectroscopy is a technique that provides unique insight into the redox biochemistry, due to its ability to: (i) distinguish and quantify different reactive species, such as hydroxyl radical, superoxide, carbon centered radicals, hydrogen atom, nitric oxide, ascorbyl radical, melanin, and others; (ii) evaluate the antioxidative capacity of various compounds, extracts and foods; (iii) provide information on other important parameters of biological systems. A combination of EPR spectroscopy and traditional biochemical methods represents an efficient tool in the studies of disease mechanisms and antioxidative therapy prospects, providing a more complete view into the redox processes in the human organism.

【 授权许可】

Unknown