Chiral Stationary Phases for Liquid Chromatography: Recent Developments

Molecules

Joana Teixeira¹  Madalena M. M. Pinto¹  Maria Elizabeth Tiritan¹  Carla Fernandes¹ 

[1] Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;

关键词: liquid chromatography;    enantioseparation;    chiral stationary phase;    chiral selector;    chromatographic support;   

DOI  :  10.3390/molecules24050865

来源: DOAJ

【 摘 要 】

The planning and development of new chiral stationary phases (CSPs) for liquid chromatography (LC) are considered as continuous and evolutionary issues since the introduction of the first CSP in 1938. The main objectives of the development strategies were to attempt the improvement of the chromatographic enantioresolution performance of the CSPs as well as enlarge their versatility and range of applications. Additionally, the transition to ultra-high-performance LC were underscored. The most recent strategies have comprised the introduction of new chiral selectors, the use of new materials as chromatographic supports or the reduction of its particle size, and the application of different synthetic approaches for preparation of CSPs. This review gathered the most recent developments associated to the different types of CSPs providing an overview of the relevant advances that are arising on LC.

【 授权许可】

Unknown