Synthesis of Cellulose-2,3-bis(3,5-dimethylphenylcarbamate) in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary Phase

International Journal of Molecular Sciences

Yijun Zhang¹  Jun Chen¹  Yuping Zhang¹  Mingxian Huang¹  Lianyang Bai²  Runqiang Liu² 

[1] College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China;College of Plant Protection, Hunan Agricultural University, Changsha 410128, China;

关键词: 1-allyl-3-methyl-imidazolium chloride;    synthesis;    Cellulose-2,3-bis(3,5-dimethylphenylcarbamate);    high performance liquid chromatography;    chiral stationary phase;    enantioseparation;   

DOI  :  10.3390/ijms15046161

来源: DOAJ

【 摘 要 】

A chiral selector of cellulose-2,3-bis(3,5-dimethylphenylcarbamate) (CBDMPC) was synthesized by reacting 3,5-dimethylphenyl isocyanate with microcrystalline cellulose dissolved in an ionic liquid of 1-allyl-3-methyl-imidazolium chloride (AMIMCl). The obtained chiral selector was effectively characterized by infrared spectroscopy, elemental analysis and 1H NMR. The selector was reacted with 3-aminopropylsilanized silica gel and the CBDMPC bonded chiral stationary phase (CSP) was obtained. Chromatographic evaluation of the prepared CSPs was conducted by high performance liquid chromatographic (HPLC) and baseline separation of three typical fungicides including hexaconazole, metalaxyl and myclobutanil was achieved using n-hexane/isopropanol as the mobile phase with a flow rate 1.0 mL/min. Experimental results also showed that AMIMCl could be recycled easily and reused in the preparation of CSPs as an effective reaction media.

【 授权许可】

Unknown