A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family

Frontiers in Neurology

Fiore Manganelli¹  Stefano Tozza¹  Lucio Santoro¹  Andrea Citterio²  Maria T. Bassi²  Filippo M. Santorelli³  Filomena Caria⁴  Massimiliano Filosto⁴  Stefano Cotti Piccinelli⁴  Serena Gallo Cassarino⁴  Anna Galvagni⁴  Enrico Baldelli⁴  Alessandro Padovani⁴ 

[1] Department of Neurosciences, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, Italy;Laboratory of Molecular Biology, Scientific Institute IRCCS E. Medea, Lecco, Italy;Unit of Molecular Medicine, IRCCS Foundation Stella Maris, Pisa, Italy;Unit of Neurology, Center for Neuromuscular Diseases, ASST Spedali Civili and University of Brescia, Brescia, Italy;

关键词: HSP;    hereditary spastic paraplegia;    ataxia;    CAPN1;    calpain-1;    SCA;   

DOI  :  10.3389/fneur.2019.00580

来源: DOAJ

【 摘 要 】

CAPN1 encodes calpain-1, a large subunit of μ-calpain, a calcium-activated cysteine protease widely present in the central nervous system. Mutations in CAPN1 have recently been identified in a complicated form of Hereditary Spastic Paraplegia (HSP) with a combination of cerebellar ataxia and corticomotor tract disorder (SPG76). Therefore, CAPN1 is now considered one of those genes that clinically manifest with a spectrum of disorders ranging from spasticity to cerebellar ataxia and represent a link between Spinocerebellar Ataxia and HSP, two groups of diseases previously considered separate but sharing pathophysiological pathways. We here describe clinical and molecular findings of two Italian adult siblings affected with a pure form of HSP and harboring the novel homozygote c.959delA variant (p.Tyr320Leufs*73) in the CAPN1 gene. Although the reason why mutations in CAPN1 may cause heterogeneous clinical pictures remains speculative, our findings confirm that the spectrum of the CAPN1-linked phenotypes includes pure HSP with onset during the third decade of life. Further studies are warrantied in order to clarify the mechanism underlying the differences in CAPN1 mutation clinical expression.

【 授权许可】

Unknown