Amyotrophic Lateral Sclerosis and Primary Biliary Cirrhosis Overlap Syndrome: Two Cases Report

Frontiers in Neurology

Weijing Qi¹  Ting Zhang²  Haibo Zhang²  Xiangyu Nie²  Zhenfei Li²  Na Liang²  Xiaomeng Zhou²  Yaling Liu³ 

[1] Department of Neurology, Baoding First Central Hospital of Hebei Province, Baoding, China;Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China;Key Laboratory of Neurology of Hebei Province, Shijiazhuang, China;

关键词: amyotrophic lateral sclerosis;    primary biliary cirrhosis;    immunological mechanism;    mitochondrial mechanism;    ursodeoxycholic acid;   

DOI  :  10.3389/fneur.2019.00890

来源: DOAJ

【 摘 要 】

Amyotrophic lateral sclerosis (ALS) is a disease of which the underlying etiology and pathogenesis are unknown. Numerous data indicate an important role of the immune system and mitochondrial function in the disease. Primary biliary cirrhosis (PBC) is an autoimmune liver disease resulting from a combination of genetic and environmental risk factors. Patients with PBC develop innate and adaptive immune reactions against mitochondrial antigens. Therefore, common mechanisms could exist in both diseases. We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients.

【 授权许可】

Unknown