期刊论文详细信息
International Journal of Molecular Sciences
Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery
Tobias Schuerholz1  Gereon Schälte2  Christian Stoppe3  Lukas Martin3  Gernot Marx3  Ann Christina Foldenauer4  Alexander Gombert5  Jochen Grommes5  Johannes Kalder5  Michael Jacobs5 
[1] Department of Anaesthesia and Intensive Care, University of Rostock, 18059 Rostock, Germany;Department of Anesthesiology, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany;Department of Intensive Care and Intermediate Care, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany;Department of Medical Statistics, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany;European Vascular Center Aachen-Maastricht, Department of Vascular Surgery University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany;
关键词: macrophage migration inhibitory factor;    thoracoabdominal aortic aneurysm;    intensive care unit;    survival;   
DOI  :  10.3390/ijms18112374
来源: DOAJ
【 摘 要 】

The perioperative inflammatory response is associated with outcome after complex aortic repair. Macrophage migration inhibitory factor (MIF) shows protective effects in ischemia-reperfusion (IR), but also adverse pro-inflammatory effects in acute inflammation, potentially leading to adverse outcome, which should be investigated in this trial. This prospective study enrolled 52 patients, of whom 29 (55.7%) underwent open repair (OR) and 23 (44.3%) underwent endovascular repair (ER) between 2014 and 2015. MIF serum levels were measured until 72 h post-operatively. We used linear mixed models and ROC analysis to analyze the MIF time-course and its diagnostic ability. Compared to ER, OR induced higher MIF release perioperatively; at 12 h after ICU admission, MIF levels were similar between groups. MIF course was significantly influenced by baseline MIF level (P = 0.0016) and acute physiology and chronic health evaluation (APACHE) II score (P = 0.0005). MIF level at 24 h after ICU admission showed good diagnostic value regarding patient survival [sensitivity, 80.0% (28.4–99.5%); specificity, 51.2% (35.1–67.1%); AUC, 0.688 (0.534–0.816)] and discharge modality [sensitivity, 87.5% (47.3–99.7%); specificity, 73.7% (56.9–86.6%), AUC, 0.789 (0.644–0.896)]. Increased perioperative MIF-levels are related to an increased risk of adverse outcome in complex aortic surgery and may represent a biomarker for risk stratification in complex aortic surgery.

【 授权许可】

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