Antibiotic‐induced reduction of abnormal lung shadow in pulmonary nodular lymphoid hyperplasia

Respirology Case Reports

Akari Tanino¹  Shunichi Hamaguchi¹  Yukari Tsubata¹  Takeshi Isobe¹  Mamiko Nagase²  Akihisa Sutani³ 

[1] Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine Shimane University Faculty of Medicine Izumo Japan;Department of Organ Pathology Shimane University Faculty of Medicine Izumo Japan;Sutani Clinic Pulmonary Medicine Izumo Japan;

关键词: Antibiotics;    Actinomyces;    lung;    nodular lymphoid hyperplasia;    pseudolymphoma;   

DOI  :  10.1002/rcr2.522

来源: DOAJ

【 摘 要 】

Pulmonary nodular lymphoid hyperplasia (PNLH) involves proliferative lymphatic tissues and is reportedly associated with inflammatory disease or autoimmune disorders. Herein, we describe a case of PNLH with difficult diagnosis because of antibiotics therapy‐induced reduction in the abnormal tumour shadow. An 86‐year‐old man was admitted for persistent cough and bloody sputum. Computed tomography (CT) revealed a mass in the right middle lobe, which got smaller on treatment with tosufloxacin for pneumonia. Unexpectedly, the tumour shadow remained one month later. Positron emission tomography depicted fluorodeoxyglucose uptake at the site. Although lung cancer was suspected, the mass was non‐diagnostic on transbronchial and CT‐guided biopsies. He was eventually diagnosed with PNLH on post‐surgical histological analysis of the lung mass. Neutrophil accumulation and bacterial lumps were present, indicating Actinomyces infection in the pulmonary alveolus, suggesting that PNLH was associated with pneumonia. Histopathological examination helped identify the aetiology of this rare case of PNLH.

【 授权许可】

Unknown