Eradication of Helicobacter pylori alleviates lipid metabolism deterioration: a large-cohort propensity score-matched analysis

Lipids in Health and Disease

Weijun Wang¹  Zeyu Wang¹  Mengke Fan¹  Rong Lin¹  Hailing Yao¹  Rui Gong²  Sanping Xu²  Junchao Zeng² 

[1] Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology;

关键词: Helicobacter pylori;    Eradication treatment;    Lipid metabolism;    High-density lipoprotein (HDL);    Low-density lipoprotein (LDL);    Lipid deterioration;   

DOI  :  10.1186/s12944-022-01639-5

来源: DOAJ

【 摘 要 】

Abstract Background The impact of Helicobacter pylori (H. pylori) eradication on metabolism of lipid and the potential predictor of such changes remain unclear. Methods This study retrospectively included subjects who underwent at least two 13C urea breath tests between 2015 and 2019 at Wuhan Union Hospital. Based on two H. pylori 13C examination results, subjects were divided into propensity score-matched persistently negative (HPN), persistently positive (HPP), and eradication (HPE) groups. The changes in lipid measurements from before to after H. pylori eradication, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglycerides, were compared within and between groups. Forty-two candidate factors were tested for their ability to predict lipid metabolism changes after H. pylori eradication. Results After propensity score matching, 3412 matched cases were analyzed. Within-group comparisons showed significantly decreased HDL (P <  0.001) and increased LDL (P <  0.001) at the second examination in both the HPE and HPP groups. Between-group comparisons showed that the HDL decrease of the HPE group was significantly larger and smaller when compared with the HPN (P = 0.001) and HPP (P = 0.004) group, respectively. Uni- and multivariate analyses showed that low diastolic blood pressure (DBP) (P = 0.002) and high mean platelet volume (MPV) (P = 0.001) before eradication were associated with increased HDL after eradication. Low total protein (TP) (P <  0.001) was associated with decreased LDL after eradication. Conclusions Compared with sustained H. pylori infectious states, H. pylori eradication alleviated the lipid metabolism deterioration but did not restore it to the uninfected level within 1.5 years after eradication. Patients with low DBP, high MPV, and low TP may reap a greater lipid-metabolism benefit from H. pylori eradication.

【 授权许可】

Unknown