Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum

Maryam Najafifard¹  Maryam Niksokhan¹  Nasrin Heidarieh¹  Maryam Khoshsokhan¹  Masomeh Najafifard¹ 

[1] Islamic Azad University of Qom;

关键词: aloe vera;    pentylenetetrazol;    seizures;    mice;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background and Objectives: Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for such researches. This study investigated the effects of Aloe vera latex on seizure in male mice.   Methods: Two groups of mice (n=8) and placebo were tested. The control group received Saline and the experimental group received Aloe vera latex (15, 25 and 50mg/kg) and half an hour later PTZ (80mg/kg) was injected intraperitoneally. Immediately after injection of PTZ, seizure threshold and duration of seizure were recorded. Data were analyzed by ANOVA and Tukey's test. p<0.05 was considered statistically significant.   Results: The group receiving a 25mg/kg dose of Aloe vera latex showed a significant increase in seizure threshold and a significant decrease in duration of seizure as compared with placebo group receiving saline (p<0.05).   Conclusion: The results of this study indicated the anticonvulsant effect of Aloe vera latex.

【 授权许可】

Unknown