Effects of misoprostrol on pentylenetetrazol-induced seizures in mice

Arquivos de Neuro-Psiquiatria

Francisco Das Chagas Medeiros¹  Maria Angelina Medeiros¹  Vietla Satyanarayna Rao¹  Eberval Gadelha Figueiredo¹ 

[1],Universidade Federal do Ceará Centro de Ciências da Saúde Departamento de Fisiologia e FarmacologiaFortaleza,Brasil

关键词: seizures;    pentylenetetrazol;    misoprostol;    mice;    convulsões;    pentilenotetrazol;    misoprostrol;    camundongos;   

DOI  :  10.1590/S0004-282X1997000500001

来源: SciELO

【 摘 要 】

The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.

【 授权许可】

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