An efficient one-pot multi component synthesis of polyhydroquinoline derivatives through Hantzsch reaction catalysed by Gadolinium triflate

Arabian Journal of Chemistry

关键词: Gadolinium triflate;    1,4-Dihydropyridine;    Hantzsch reaction;    One-pot synthesis;    Multi component reaction;   

DOI  :  10.1016/j.arabjc.2012.10.017

来源: DOAJ

【 摘 要 】

Gadolinium(III) trifluoromethanesulfonate (Gadolinium triflate) Gd(OTf)3 catalysed efficient Hantzsch reaction via four-component coupling reactions of aldehydes, 5,5-dimethyl-1,3-cyclohexaedione (dimedone), ethyl acetoacetate and ammonium acetate at ambient temperature was described as the preparation of polyhydroquinoline derivatives. The process presented here is operationally simple, environmentally benign and has excellent yield. Furthermore, the catalyst can be recovered conveniently and reused efficiently.

【 授权许可】

Unknown