Evolutionary Pattern and Large-Scale Architecture of Mutation Networks of 2009 A (H1N1) Influenza A Virus

Frontiers in Genetics

Liang Wang¹  Xueze Lyv¹  Xiaodong Liu¹  Jing Wang²  Wenwen Gu²  Hua Ding²  Yan Wu²  Yi Tao³  Jing Luo³  Nan Lyu³  Lingling Deng³  Hongxuan He³  Chengmin Wang³ 

[1] Beijing Animal Husbandry Station, Beijing, China;Department of Infectious Diseases, Hangzhou Center for Disease Control and Prevention, Hangzhou, China;Key Lab of Animal Ecology and Conservation Biology, National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;

关键词: evolutionary pattern;    influenza A virus;    scale-free mutation network;    H1N1;    complete genome;   

DOI  :  10.3389/fgene.2018.00204

来源: DOAJ

【 摘 要 】

The adaptive evolution of influenza virus is an important question, but predicting its evolutionary future will be more challenging. Here, we investigated the mutation characteristic of influenza virus based on the complete genome data of 2009 (H1N1) influenza A virus. By assuming that evolution proceeds via the accumulation of mutations, we analyzed the mutation networks at four different time stages and found that the network structure follows the characteristics of a scale-free network. These results will be important for epidemiology and the future control of influenza viruses. Furthermore, we predicted the predominant mutation virus strain by using the early mutation network of influenza viruses, and this result was consistent with the WHO recommendation for the candidate vaccine of influenza virus. The key contribution of this study is that we explained the biological significance of this scale-free network for influenza pandemic and provided a potential method for predicting the candidate vaccine by using the early-stage network.

【 授权许可】

Unknown