Neurological complications after H1N1 influenza vaccination: magnetic resonance imaging findings

Arquivos de Neuro-Psiquiatria

Ronaldo Lessa¹  Maurício Castillo¹  Renata Azevedo¹  Fernanda Azevedo¹  Hildo Azevedo¹ 

关键词: central nervous system;    influenza A virus;    H1N1;    magnetic resonance imaging;    encephalitis after vaccination;    sistema nervoso central;    virus influenza H1N1;    imagem de ressonância magnética;    encefalite pós-vacinal;   

DOI  :  10.1590/0004-282X20140064

来源: SciELO

【 摘 要 】

Objective:To report 4 different neurological complications of H1N1 virus vaccination. Method:Four patients (9, 16, 37 and 69 years of age) had neurological symptoms (intracranial hypertension, ataxia, left peripheral facial palsy of abrupt onset, altered mental status, myelitis) starting 4-15 days after H1N1 vaccination. MRI was obtained during the acute period. Results:One patient with high T2 signal in the cerebellum interpreted as acute cerebellitis; another, with left facial palsy, showed contrast enhancement within both internal auditory canals was present, however it was more important in the right side; one patient showed gyriform hyperintensities on FLAIR with sulcal effacement in the right fronto-parietal region; and the last one showed findings compatible with thoracic myelitis. Conclusion:H1N1 vaccination can result in important neurological complications probably secondary to post-vaccination inflammation. MRI detected abnormalities in all patients.

【 授权许可】

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