Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae

Emerging Infectious Diseases

关键词: Mycobacterium tuberculosis;    Mycobacterium tuberculosis complex;    bacteria;    tuberculosis and other mycobacteria;    genotypes;    animal-adapted;   

DOI  :  10.3201/eid2807.212353

来源: DOAJ

【 摘 要 】

We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the samespoligotype as M. caprae strains, single-nucleotide polymorphism–based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC.

【 授权许可】

Unknown