期刊论文详细信息
International Journal of Molecular Sciences
Apoptosis in Cellular Society: Communication between Apoptotic Cells and Their Neighbors
Erina Kuranaga1  Yuhei Kawamoto1  Yu-ichiro Nakajima2 
[1] Laboratory for Histogenetic Dynamics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan;Laboratory for Histogenetic Dynamics, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan;
关键词: apoptosis;    non-cell autonomous effects;    engulfment;    proliferation;    mechanical force;   
DOI  :  10.3390/ijms17122144
来源: DOAJ
【 摘 要 】

Apoptosis is one of the cell-intrinsic suicide programs and is an essential cellular behavior for animal development and homeostasis. Traditionally, apoptosis has been regarded as a cell-autonomous phenomenon. However, recent in vivo genetic studies have revealed that apoptotic cells actively influence the behaviors of surrounding cells, including engulfment, proliferation, and production of mechanical forces. Such interactions can be bidirectional, and apoptosis is non-autonomously induced in a cellular community. Of note, it is becoming evident that active communication between apoptotic cells and living cells contributes to physiological processes during tissue remodeling, regeneration, and morphogenesis. In this review, we focus on the mutual interactions between apoptotic cells and their neighbors in cellular society and discuss issues relevant to future studies of apoptosis.

【 授权许可】

Unknown   

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