New Ionic Carbosilane Dendrons Possessing Fluorinated Tails at Different Locations on the Skeleton

Molecules

Mercedes Valiente¹  Gabriel Mencia²  Javier de la Mata²  Tania Lozano-Cruz²  Jesús Cano²  Rafael Gómez² 

[1] Departamento de Química Analítica, Química Física e Ingeniería Química, IQAR, Universidad de Alcalá Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain;Departamento de Química Orgánica y Química Inorgánica, IQAR, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, 28805 Madrid, Spain;

关键词: carbosilane;    dendrimer;    fluorine;    micelle;   

DOI  :  10.3390/molecules25040807

来源: DOAJ

【 摘 要 】

The fluorination of dendritic structures has attracted special attention in terms of self-assembly processes and biological applications. The presence of fluorine increases the hydrophobicity of the molecule, resulting in a better interaction with biological membranes and viability. In addition, the development of ¹⁹F magnetic resonance imaging (¹⁹F-MRI) has greatly increased interest in the design of new fluorinated structures with specific properties. Here, we present the synthesis of new water-soluble fluorinated carbosilane dendrons containing fluorinated chains in different positions on the skeleton, focal point or surface, and their preliminary supramolecular aggregation studies. These new dendritic systems could be considered as potential systems to be employed in drug delivery or gene therapy and monitored by ¹⁹F-MRI.

【 授权许可】

Unknown