Can nanotechnology potentiate photodynamic therapy?

Nanotechnology Reviews

article

Ying-Ying Huang¹  Sulbha K. Sharma¹  Tianhong Dai¹  Hoon Chung¹  Anastasia Yaroslavsky¹  Maria Garcia-Diaz¹  Julie Chang¹  Long Y. Chiang⁷  Michael R. Hamblin¹ 

[1] Wellman Center for Photomedicine, Massachusetts General Hospital;Department of Dermatology, Harvard Medical School;Aesthetic and Plastic Center, Guangxi Medical University;College of Engineering, Boston University;Institut Qu í mic de Sarri à, Universitat Ramon Llull;Department of Chemistry, Harvard University;Department of Chemistry, University of Massachusetts;Harvard-MIT Division of Health Sciences and Technology

关键词: dendrimer;    fullerene;    graphene;    lipoplex;    lipoprotein;    liposome;    magnetic nanoparticle;    micelle;    nanocell;    nanoparticle;    ORMOSIL;    polymeric nanoparticle;    porphysome;    quantum dot;    single-walled carbon nanotube;    two-photon excitation;    upconversion;   

DOI  :  10.1515/ntrev-2011-0005

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”.

【 授权许可】

CC BY