Parcellation‐based anatomic modeling of the default mode network

Brain and Behavior

Michael E. Sughrue¹  Vukshitha Dhanaraj¹  Rannulu Dineth Fonseka¹  Michael Y. Bai¹  Onur Tanglay¹  Yueh‐Hsin Lin¹  Jorge Hormovas¹  Isabella M. Young²  Andrew K. Conner³  Zainab Sandhu³  Chad A. Glenn³  Micah L. Larsen³  Robert G. Briggs³ 

[1] Centre for Minimally Invasive Neurosurgery Prince of Wales Private Hospital Sydney NSW Australia;Cingulum Health Sydney NSW Australia;Department of Neurosurgery University of Oklahoma Health Sciences Center Oklahoma City OK USA;

关键词: ALE;    anatomy;    default mode network;    parcellation;    tractography;    white matter;   

DOI  :  10.1002/brb3.1976

来源: DOAJ

【 摘 要 】

Abstract Background The default mode network (DMN) is an important mediator of passive states of mind. Multiple cortical areas, such as the anterior cingulate cortex, posterior cingulate cortex, and lateral parietal lobe, have been linked in this processing, though knowledge of network connectivity had limited tractographic specificity. Methods Using resting‐state fMRI studies related to the DMN, we generated an activation likelihood estimation (ALE). We built a tractographical model of this network based on the cortical parcellation scheme previously published under the Human Connectome Project. DSI‐based fiber tractography was performed to determine the structural connections between cortical parcellations comprising the network. Results Seventeen cortical regions were found to be part of the DMN: 10r, 31a, 31pd, 31pv, a24, d23ab, IP1, p32, POS1, POS2, RSC, PFm, PGi, PGs, s32, TPOJ3, and v23ab. These regions showed consistent interconnections between adjacent parcellations, and the cingulum was found to connect the anterior and posterior cingulate clusters within the network. Conclusions We present a preliminary anatomic model of the default mode network. Further studies may refine this model with the ultimate goal of clinical application.

【 授权许可】

Unknown