Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques

eLife

Gang Li¹  Lingzhong Fan²  Chet Sherwood³  Yuanchao Zhang⁴  Luqi Cheng⁵  Tianzi Jiang⁶  Jiaojian Wang⁷  Gaolang Gong⁸ 

[1] Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China;Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, United States;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen, China;State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China;Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China;

关键词: inferior parietal lobule;    brain asymmetry;    brain evolution;    anatomical connectivity;    parcellation;    Human;    Rhesus macaque;    Other;   

DOI  :  10.7554/eLife.67600

来源: eLife Sciences Publications, Ltd

【 摘 要 】

The inferior parietal lobule (IPL) is one of the most expanded cortical regions in humans relative to other primates. It is also among the most structurally and functionally asymmetric regions in the human cerebral cortex. Whether the structural and connectional asymmetries of IPL subdivisions differ across primate species and how this relates to functional asymmetries remain unclear. We identified IPL subregions that exhibited positive allometric in both hemispheres, scaling across rhesus macaque monkeys, chimpanzees, and humans. The patterns of IPL subregions asymmetry were similar in chimpanzees and humans, but no IPL asymmetries were evident in macaques. Among the comparative sample of primates, humans showed the most widespread asymmetric connections in the frontal, parietal, and temporal cortices, constituting leftward asymmetric networks that may provide an anatomical basis for language and tool use. Unique human asymmetric connectivity between the IPL and primary motor cortex might be related to handedness. These findings suggest that structural and connectional asymmetries may underlie hemispheric specialization of the human brain.

【 授权许可】

CC BY