期刊论文详细信息
Frontiers in Psychiatry
Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy
Tianzi Jiang2  Lingzhong Fan2  Hua Zhao3  Shuxin Luan4  Lei Zhang4  Qi Tao5  Hongyan Yu8  Xueqin Song1,11  Luxian Lv1,12  Yongfeng Yang1,13 
[1] 0National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China;1University of Chinese Academy of Sciences, Beijing, China;2Department of Physiology, College of Basic Medical Sciences, Jilin University, Jilin, China;3Department of Psychiatry, The First Bethune Hospital of Jilin University, Changchun, China;Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China;Biological Psychiatry International Joint Laboratory of Henan, Zhengzhou University, Zhengzhou, China;Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China;Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China;Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, China;Henan Psychiatric Transformation Research Key Laboratory, Zhengzhou University, Zhengzhou, China;International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, China;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;
关键词: treatment-resistant depression (TRD);    transcranial magnetic stimulation (TMS);    anatomical connectivity;    subgenual anterior cingulated cortex (sACC);    prefrontal cortex (PFC);   
DOI  :  10.3389/fpsyt.2020.00236
来源: DOAJ
【 摘 要 】

ObjectivesAbnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting the sACC as a potentially effective target for therapeutic modulation in cases resistant to conventional treatments (treatment-resistant depression, TRD). We hypothesized that areas in the prefrontal cortex (PFC) with direct fiber connections to the sACC may be particularly effective sites for treatment using transcranial magnetic stimulation (TMS). The aim of this study was to identify PFC sites most strongly connected to the sACC.MethodsTwo neuroimaging data sets were used to construct anatomic and functional connectivity maps using sACC as the seed region. Data set 1 included magnetic resonance (MR) images from 20 healthy controls and Data set 2 included MR images from 15 TRD patients and 15 additional healthy controls. PFC voxels with maximum values in the mean anatomic connection probability maps were identified as optimal sites for TMS.ResultsBoth right and left PFC contained sites strongly connected to the sACC, but the coordinates (in Montreal Neurological Institute space) of peak anatomic connectivity differed slightly between hemispheres. The left PFC site connected directly to the sACC both anatomically and functionally, while the right PFC site was functionally connected to the posterior cingulate cortex (PCC).ConclusionsBoth left and right PFC are functionally connected to regions implicated in depression, the sACC and PCC, respectively. These bilateral PFC sites may be effective TMS targets to treat TRD.

【 授权许可】

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