Echocardiographic evaluation of diastolic dysfunction in young and healthy patients with psoriasis: A case-control study

Monaldi Archives for Chest Disease

Mariachiara Arisi¹  Piergiacomo Calzavara Pinton¹  Elio Gorga²  Renzo D'Ortona²  Marco Metra²  Ivano Bonadei²  Edoardo Sciatti²  Enrico Vizzardi²  Marta Scodro²  Francesca Valentini²  Valentina Regazzoni² 

[1] University of Brescia, Department of Dermatology, Spedali Civili of Brescia;University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health;

关键词: Psoriasis;    diastolic disfunction;    cardiovascular risk;    atherosclerosis;    echocardiography.;   

DOI  :  10.4081/monaldi.2018.934

来源: DOAJ

【 摘 要 】

Psoriasis is a systemic inflammatory disease with a great prevalence in general population. The inappropriate activation of the cellular immune system has been hypothesized to be an independent cardiovascular risk factor, given the higher incidence of cardiovascular disorders in psoriatic patients. Echocardiographic abnormalities have been demonstrated too: the aim of our study was to evaluate the presence of preclinical cardiac dysfunction in a cohort of psoriatic patients without cardiovascular risk factors. We enrolled 52 patients with the diagnosis of chronic plaque psoriasis, compared with a control group not affected by any relevant systemic diseases and inflammatory disorders. In all patients and control group, echocardiographic conventional and tissue Doppler (TDI) studies were conducted. The analysis of echocardiographic parameters revealed normal dimension, mass and systolic function of the left ventricle. Left ventricular diastolic dysfunction was found in 36.5% patients in the psoriasis group versus 0% in control group, and significant reduction of the E/A ratio was found also for the right ventricle. A significant increase of mitral regurgitation has been found in psoriatic patients (p=0.005). The early recognition of cardiovascular pre-clinic disease in psoriatic patients may guide a strict follow up and an early treatment, potentially improving cardiovascular prognosis.

【 授权许可】

Unknown