Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release

Nano Select

Long Tran¹  Zhen Qiao¹  Hai‐Feng Ji¹  Jesse Parks¹  Nan Hai²  Yao Zhao²  Yinghui Zhong² 

[1] Department of Chemistry Drexel University Philadelphia Pennsylvania 19104 USA;School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia Pennsylvania 19104 USA;

关键词: chemical crosslinking;    drug delivery;    highly stretchable;    hydrogel;    physical crosslinking;    polyacrylamide;   

DOI  :  10.1002/nano.202000087

来源: DOAJ

【 摘 要 】

Abstract Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications. Four drug compounds, nicotine, lidocaine hydrochloride, diltiazem hydrochloride and diclofenac sodium, were used for the evaluation. The release rates of these compounds follow an order: lidocaine > diltiazem > nicotine > diclofenac, which showed a strong correlation between the release rate with their solubility in water at pH 5.5. The kinetics study showed a linear and sustainable release of all tested drugs in the first 8 hours. Experiments were conducted in vitro on replicated human skin. Cytotoxicity studies indicate hydrogel is nontoxic to human cells. The highly stretchable and tough characters of the hydrogel the strength of the hydrogel reduce the severity of wear and tear issues over time for transdermal drug release.

【 授权许可】

Unknown