Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: a pilot study

Pteridines

Melichar Bohuslav¹  Študentová Hana¹  Mohelníková-Duchoňová Beatrice¹  Mergancová Jana²  Mergancová Jindřiška²  Šiller Jiří²  Sákra Lukáš²  Klos Dušan³  Javorská Lenka⁴  Krčmová Lenka Kujovská⁴  Solichová Dagmar⁴ 

[1] Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech Republic;Department of Surgery, Pardubice General Hospital, Pardubice, Czech Republic;First Department of Surgery, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Third Department of Medicine (Gerontology and Metabolic Care), Charles University Teaching Hospital, Hradec Králové, Czech Republic;

关键词: breast cancer;    kynurenine;    melanoma;    neopterin;    tryptophan;   

DOI  :  10.1515/pterid-2017-0018

来源: DOAJ

【 摘 要 】

The aim of the present pilot study was to investigate the concentrations of neopterin, kynurenine and tryptophan in wound secretion in patients undergoing surgery for breast cancer or malignant melanoma. Twenty-two patients, 16 females and 6 males, undergoing surgery for breast cancer (n=15) or malignant melanoma (n=7) were evaluated. Neopterin, kynurenine and tryptophan were determined using a high-performance liquid chromatography method. When the concentrations in wound secretions from the primary breast tumor and the axilla were compared, the neopterin/tryptophan ratio was significantly higher in the tumor wound secretions (0.92±0.41 vs. 0.61±0.14 mmol/mol; p=0.049), but no significant differences were observed in neopterin (49.2±28.6 vs. 31.5±11.1 nmol/L), tryptophan (52.9±13.0 vs. 51.2±13.3 μmol/L) and kynurenine concentrations (5.97±7.49 vs. 5.34±6.25 μmol/L) and kynurenine/tryptophan ratio (108.1±107.7 vs. 103.5±106.7 mmol/mol). No marked differences were noted in neopterin, tryptophan and kynurenine concentrations and kynurenine/tryptophan and neopterin/tryptophan ratios in sequential samples from the axilla of breast cancer patients obtained on days 1 and 2. In conclusion, present data demonstrate that the measurement of neopterin, kynurenine and tryptophan can be used to monitor local immune response after cancer surgery.

【 授权许可】

Unknown