Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

Frontiers in Pediatrics

Elie Haddad¹  Manfred Hoenig² 

[1] CHU Sainte-Justine, Department of Pediatrics, Microbiology, Immunology and Infectious Diseases, University of Montreal, Montreal, QC, Canada;Department of Pediatrics, University Medical Center Ulm, Ulm, Germany;

关键词: severe combined immunodeficiency;    SCID;    clinical presentation;    infections;    hematopoietic stem cell transplantation;    HSCT;   

DOI  :  10.3389/fped.2019.00481

来源: DOAJ

【 摘 要 】

Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered.

【 授权许可】

Unknown