Alcohol Consumption and Hepatitis C Virus (HCV) RNA Levels in HIV/HCV Coinfected Patients

Viruses

JeffreyH. Samet¹  DebbieM. Cheng¹  Richard Saitz¹  Daniel Fuster²  David Nunes³ 

[1] Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA;Department of Internal Medicine, Addiction Unit Hospital Universitari Germans Trias i Pujol, Department of Medicine, Universitat Autònoma de Barcelona, 08916 Badalona, Spain;Section of Gastroenterology, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA;

关键词: HIV;    chronic HCV infection;    HCV RNA levels;    alcohol use disorder;    unhealthy alcohol use;    alcohol;   

DOI  :  10.3390/v13050716

来源: DOAJ

【 摘 要 】

Background: The impact of Hepatitis C virus (HCV) RNA levels on the evolution of chronic HCV infection-related liver damage is controversial. Heavy alcohol use is believed to have a deleterious impact on the course of HCV disease, but current knowledge about the possible effect of alcohol use on HCV RNA levels in HIV/HCV coinfected patients is limited. Methods: We examined 107 HIV/HCV-infected individuals with current or past unhealthy alcohol use to assess the association between alcohol consumption (any drinking vs. abstinent) and HCV RNA levels. Results: Participants were 75% male, with a mean age of 43 years, and 63% were on antiretroviral therapy. Mean (SD) log HIV RNA was 3.1 (1.4) and mean (SD) log HCV RNA was 6.1 (0.8). Past-month alcohol use was present in 38% of participants. In a multivariable linear regression analysis we found no significant differences in mean log HCV RNA levels between those reporting alcohol use and those who were abstinent [β (95%CI): −0.04 (−0.34, 0.26), p = 0.79)]. There was no significant association between any heavy drinking day and HCV RNA level (0.07, 95% CI: (−0.24, 0.38), p = 0.66). Conclusions: We did not detect significant associations between alcohol use and HCV RNA levels among HIV/HCV coinfected patients.

【 授权许可】

Unknown