The structure of the serotonin system: A PET imaging study

NeuroImage

Gitte Moos Knudsen¹  Stephen Strother²  Claus Svarer³  Brice Ozenne⁴  Melanie Ganz⁴  Vincent Beliveau⁴  Douglas N. Greve⁵ 

[1] Harvard Medical School, Boston, MA, USA;Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA;Neurobiology Research Unit, Copenhagen, Denmark;Rotman Research Institute, Baycrest, and Department of Medical Biophysics, University of Toronto, Toronto, Canada;

关键词: Serotonin;    PET;    MRI;    Clustering;    Structure;    mRNA;   

DOI  :  

来源: DOAJ

【 摘 要 】

The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

【 授权许可】

Unknown