From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

Frontiers in Medicine

Heinrich Schrewe¹  Catherine Chaussain²  Céline Gaucher²  Anne-Laure Bonnet²  Gaël Y. Rochefort³  Isabelle Broutin⁴ 

[1] Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany;Department of Odontology, University Hospitals Charles Foix, PNVS, and Henri Mondor, AP-HP, Paris, France;EA 2496 Orofacial Pathologies, Imaging and Biotherapies, Dental School Faculty, University Paris Descartes and Life Imaging Platform (PIV), Montrouge, France;Laboratoire de Cristallographie et RMN Biologiques (UMR 8015, CNRS), Pharmacy Faculty, University Paris Descartes, USPC, Paris, France;

关键词: Slitl2;    TGF-β;    Notch1;    biomarker;    development;    pathophysiology;   

DOI  :  10.3389/fmed.2018.00335

来源: DOAJ

【 摘 要 】

First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.

【 授权许可】

Unknown