Frontiers in Medicine | |
From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin? | |
Anne-Laure Bonnet1  | |
关键词: Slitl2; TGF-β; Notch1; biomarker; development; pathophysiology; | |
DOI : 10.3389/fmed.2018.00335 | |
学科分类:医学(综合) | |
来源: Frontiers | |
【 摘 要 】
First described in 1988, vasorin (VASN) is a transmembrane glycoprotein expressed during early mouse development, and with a less extent, in various organs and tissues (e.g., kidney, aorta, and brain) postnatally. Vasn KO mice die after 3 weeks of life from unknown cause(s). No human disease has been associated with variants of this gene so far, but VASN seems to be a potential biomarker for nephropathies and tumorigenesis. Its interactions with the TGF-β and Notch1 pathways offer the most serious assumptions regarding VASN functions. In this review, we will describe current knowledge about this glycoprotein and discuss its implication in various organ pathophysiology.
【 授权许可】
CC BY
【 预 览 】
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RO201904027083583ZK.pdf | 1165KB | download |