Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm

Materials

Michael D. Weir¹  Mingyun Li¹  Hockin H. K. Xu²  Mingye Feng²  Suping Wang³  Biao Ren³  Qi Han³  Xian Peng³  Keke Zhang³  Lei Cheng³  Xuedong Zhou³  Hui Chen³ 

[1] Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA;;Biomaterials &State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China;

关键词: heat-polymerized resin;    dimethylaminododecyl methacrylate;    Candida albicans biofilms;    denture stomatitis;    antifungal properties.;   

DOI  :  10.3390/ma10040431

来源: DOAJ

【 摘 要 】

The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin. The specimens were incubated with C. albicans solution in medium to form biofilms. Then Colony-Forming Units, XTT assay, and scanning electron microscope were used to evaluate antifungal effect of DMADDM-modified resin. DMADDM modified acrylic resin had no effect on the flexural strength, bond quality, and surface roughness, but it increased the surface charge density significantly. Meanwhile, this new resin inhibited the C. albicans biofilm significantly according to the XTT assay and CFU counting. The hyphae in C. albicans biofilm also reduced in DMADDM-containing groups observed by SEM. DMADDM modified acrylic resin was effective in the inhibition of C. albicans biofilm with good physical properties.

【 授权许可】

Unknown