Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor

Marine Drugs

Yonghui Zhang¹  Weiguang Sun¹  Huaqiang Li¹  Changxing Qi¹  Hucheng Zhu¹  Zengwei Luo¹  Yongbo Xue¹  Mengyi Deng¹  Chunmei Chen¹  Jianping Wang¹ 

[1] Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;

关键词: Aspergillus versicolor;    meroterpenoids;    asperversins;    acetylcholinesterase enzyme;   

DOI  :  10.3390/md16060177

来源: DOAJ

【 摘 要 】

Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM.

【 授权许可】

Unknown